In order to investigate the effect of Panax ginseng extract and it´s degree in mucociliary change of mice nasal septum epithelia exposured to sulfur dioxide, 96 ICR male mice were used. They were at first divided the 4th week, the 8th week or the 16th week groups according to the age after birth and 6 hour or 12 hour groups according to the SO₂ gas exposured hour in a day, and at control, 50㎎, 100㎎ and 200㎎ injection groups according to the dosage of the freeze-drying powder of the ginseng extract which was injected into the mouse peritoneal cavities in the condition of the solution solved with physiological saline solution. Each subgroups which were divided finaly incl.uded 4 male mice. The histological tissue sections for observation were made from nasal septum, posterior nasal orfice and trachea.
The results obtained by experiments were summarized as followings.
1. The loss of the nasal mucosa epithelial cilia of the mouse exponsure to the SO₂ gas after ginseng extract injection was apparently diminish compare to those exposured only SO₂ gas without pretreatment of ginseng extract (p<0.01).
2. The inhibition effect for the loss of nasal mucosa cilia according to the ginseng extract dosages not found in this research(p>0.05).
3. There were differences in the loss of nasal mucosa cilia according to the SO₂ gas exposure time between the control group and ginseng extract pretreatment group (p<0.01).
4. According to the increase of the postnatal time, there were remarkable differences between the control group and the ginseng extract pretreatment groups in the loss of nasal mucosa cilia (p<0.01).
5. Ciliary changes of the posterior nasal orifice and trachea according to the SO₂ gas exposure time, mice age and ginseng dosages, were not clearly observed in this light microscopical observation.
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